Research Associate

Performs laboratory activities to support therapy development efforts of Novasenta, a UPMC Enterprises funded biotech startup focused on developing new cancer therapies targeting immunoregulatory mechanisms in the tumor microenvironment, reporting to Principal Scientist.

Responsibilities:

  • Reports to Research Scientist to ensure meeting the goals of Novasenta and pursuing the most promising targets within the tumor microenvironment for the development of therapeutics
  • Conducts routine and non-routine lab procedures and assays for molecular, cellular and metabolic characterization of relevant samples from mouse models of cancer and human clinical cancer tissue under the supervision of Research Scientist
  • Supports the development of biological, immunological assay to investigate mechanisms of immune-mediated effects of novel identified targets
  • Supports the development and validation of new technologies for molecular, cellular and metabolic characterization of samples
  • Contributes to the profiling and validation of novel druggable immunotherapy targets
  • Documents and maintains a detailed and precise record of work performed
  • Actively participates in the scientific dialogue of the group and proactively collaborates with colleagues

Qualifications:

  • MS in biology, immunology or closed related field with 2+ years of experience in industry or academic research lab setting or PhD with similar background and 0-2 years of relevant experience
  • Prior biopharma industry or commercial research experience desired experience with several of the following relevant techniques:
    • Mammalian cell culture
    • Flow cytometry and cell sorting
    • Molecular biology techniques (e.g., PCR, development of genetic constructs, cloning, etc.)
    • NGS (WGS, WES or RNAseq, including preparation of genomic libraries)
    • CRISPR or other advanced genetic editing techniques
    • Processing and characterization of fresh human tumor samples
    • Cell-based metabolic assays
  • Ability to propose new experimental designs, plan and conduct laboratory experiments, and evaluate and interpret data
  • Fundamental understanding of the process of discovery and development of immunology-based therapeutic targets and possible novel therapeutic concepts
  • Experience in immuno-oncology-related animal studies is a plus
  • The role requires critical thinking e.g. by proposing and implementing novel experimental approaches and concepts contributing to the cancer immunology and immune therapy research goals.
  • The ideal candidate is product and goal oriented, focused on a career in biotech. They are highly efficient and organized and have a demonstrated ability to adhere to and follow defined timelines, milestone, and objectives.
  • Experience in working under GLP standards and ensuring safety compliance under BSL-2
  • Experience with laboratory information system (LIMS) is a plus
  • Good verbal and written communication skills and the ability to interpret, summarize, and present results in a clear, concise, accurate manner

What we offer you:

  • Competitive pay and benefits package.
  • A fast-paced startup culture combined with the stability of a well-established entity (UPMC).
  • Work with some of the leaders in the immunotherapy and cancer field.
  • Opportunity to be part of a growing, dynamic and diverse team of highly skilled professionals discovering novel cancer therapies and making an impact on patient care.

To apply please send your resume to info@novasenta.com with job title in the subject line.